April 20, 2017

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By Amar Chatterjee

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1992). The reduction of bone formation markers in anorexia nervosa is consistent with the proposed hypothesis that severe malnutrition may have a pronounced deleterious effect on functioning of the osteoblasts (Table 1). , 1999). The biochemical markers of bone formation (osteocalcin and bone-specific alkaline phosphatase) were significantly reduced in 19 girls with anorexia nervosa. , 1999). The IGF-1 acts as an osteotrophic hormone, which affects bone growth and bone turnover by stimulating osteoblasts, collagen synthesis and longitudinal bone growth.

1998). , 1998). , 2000; Finkelstein J. et al, 2008). In the post-menopause, the lean mass of the trunk, lower limb and of the total body, measured by DXA, is lower than in the premenopausal women and is inversely related to age and menopause duration. In postmenopausal women the loss of lean body mass is independent of the age and bodyweight. The lean body mass of the trunk declines more quickly than other areas of the body (Finkelstein J. et al, 2008). , 1999). 38 Amenorrhea A study of 129 women aged between 75 to 89 years showed that muscle mass was significantly reduced along with the incidence of osteoporosis and reduced BMD at the hip.

7 years. In these patients measurements of BMD were made at the lumbar spine and forearm. Groups were divided into three according to their stages of recovery: a. a good recovery - women who had regular cycles and not weighed less than 85% of their expected body weight, b. a poor recovery - the patients who had not reached regular cycles and weighed less than 85%, c. an intermediate stage of recovery - the patients had not yet achieved regular cycles but their body weight was found to be higher than 85% of expected body weight.

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